Today I would like to talk to you of an important news: "Spanish researchers discover an enzyme that favors cardiac hypertrophy".
Scientists at the Center for Biomedical Research in the Network of Cardiovascular Diseases (Cibercv) have found that the enzyme 'lysyl oxidase' alters diastolic function, in a way dependent on the age of the patient and also contributes to cardiac hypertrophy, induced by pressure overload.
Lysyl oxidase enzyme
Diagnostic cardiac test
In this study, published in the journal “Faseb J”, it is evident that the pharmacological control of the activity of this enzyme could be beneficial, in the treatment of heart failure and hypertrophy, a serious public health problem and one of the main causes of hospitalization, in developed countries.
In a news release, Cibercv researchers said that the enzyme 'lysyl oxidase' controls matrix remodeling, a key process underlying cardiovascular diseases and heart failure; however, “the lack of adequate animal models has limited the knowledge, until the present time, regarding the contribution of this enzyme, in the cardiac dysfunction ".
In the study they have evaluated its impact, on ventricular function and cardiac hypertrophy, in a transgenic mouse model, with a strong cardiac expression of this enzyme of human origin, evidencing the relation of the enzyme, with the alteration of the diastolic function, aggravating also the hypertrophy and cardiac dysfunction, induced by angiotensin II.
"In this regard, the researchers claim that “Our findings definitely suggest that the enzyme 'lysyl oxidase' induces a change in age-dependent diastolic function and aggravates hypertrophy, which gives us new insights into its role in Cardiac output ".
Well, I hope that you have liked this news.
Until my next post, kind regards,
Luis.
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